Corynoxine (hydrochloride)

Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.^1,2 It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM.¹ Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson's disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine and chloroquine . It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.²

1.Chen, L.-L., Song, J.-X., Lu, J.-H., et al.Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathwayJ. Neuroimmune Pharmacol.9(3)380-387(2014) 2.Sakakibara, I., Terabayashi, S., Kubo, M., et al.Effect on locomotion of indole alkaloids from the hooks of Uncaria plantsPhytomedicine6(3)163-168(1999)