Cosyntropin (acetate) (Synonyms: ACTH (1-24), Adrenocorticotropic Hormone 1-24, Tetracosactide) |
| Catalog No.GC18804 |
Cosyntropin (acetate) is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Cosyntropin (acetate) is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60189-34-6
Sample solution is provided at 25 µL, 10mM.
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Cosyntropin (acetate) is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Cosyntropin (acetate) is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis[1].
Under the stimulation of Cosyntropin (acetate) (10nM; 48h), PregS and Preg in adrenal cells showed an acute response (increased 21-fold and 12-fold respectively over the baseline within 3h) and reached a peak after 24h. In contrast, DHEAS and DHEA did not respond much to Cosyntropin (acetate) stimulation (increased 1.8-fold and 2.8-fold respectively over the baseline after 3h). After 48h of Cosyntropin (acetate) stimulation, PregS levels decreased slightly, Preg content decreased sharply, and DHEAS levels continued to increase slightly [2].
Cosyntropin (acetate) (0.2μg/kg/day; SC; 24d) stimulates vascular endothelial growth factor production in vivo and induces vascular endothelial growth factor secretion from osteoblasts via the pro-adrenocorticotropic hormone receptor, MC2R, which supports osteoblast maturation and survival in vitro[3]. Reduced microglia/macrophage accumulation and neutrophil infiltration in conjunction with moderate improvements in spatial learning in Cosyntropin (acetate) treated TBI mice[4].
References:
[1]Iuliano F, Iuliano E, Rossi M. Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation[J]. Blood, 2018, 132: 2449.
[2]. Rege J, Nanba A T, Auchus R J, et al. Adrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro[J]. The Journal of Clinical Endocrinology & Metabolism, 2018, 103(1): 320-327.
[3].Zaidi M, Sun L, Robinson L J, et al. ACTH protects against glucocorticoid-induced osteonecrosis of bone[J]. Proceedings of the National Academy of Sciences, 2010, 107(19): 8782-8787.
[4]. Siebold L, Krueger A C, Abdala J A, et al. Cosyntropin attenuates neuroinflammation in a mouse model of traumatic brain injury[J]. Frontiers in Molecular Neuroscience, 2020, 13: 109.
| Cell experiment [1]: | |
Cell lines | Adrenal cells |
Preparation Method | Adrenal cells were treated with 10nM Cosyntropin (acetate) for 48 hours. |
Reaction Conditions | 10nM; 48h |
Applications | After Cosyntropin (acetate)-stimulated conditions, PregS and Preg demonstrated abrupt acute responses (21-and 12-fold increase at 3 hours compared with baseline, respectively) and peaked after 24 hours. In contrast, DHEAS and DHEA responded only modestly to Cosyntropin (acetate) stimulation (1.8- and 2.8-fold increase at 3 hours compared with baseline, respectively). By 48 hours after Cosyntropin (acetate) stimulation, a modest decline in PregS levels and a steep drop in Preg content, whereas the DHEAS level continued to rise slightly. |
| Animal experiment [2]: | |
Animal models | Glucocorticoid-induced osteonecrosis model |
Preparation Method | We treated female rabbits averaging 4.48 kg with depot methylprednisolone acetate alone or Cosyntropin (acetate) 0.2μg/kg, daily, as an sc. injection. They were also administered 10 mg/kg tetracycline 5 days apart before sacrifice. |
Dosage form | 0.2μg/kg/day; SC; 24d |
Applications | Cosyntropin (acetate) stimulates vascular endothelial growth factor production in vivo and induces vascular endothelial growth factor secretion from osteoblasts via the pro-adrenocorticotropic hormone receptor, MC2R, which supports osteoblast maturation and survival in vitro. |
References: | |
| Cas No. | 60189-34-6 | SDF | |
| Synonyms | ACTH (1-24), Adrenocorticotropic Hormone 1-24, Tetracosactide | ||
| Chemical Name | α1-24-corticotropin, acetate | ||
| Canonical SMILES | N/A | ||
| Formula | C136H210N40O31S.XC2H4O2 | M.Wt | 2993.5 |
| Solubility | PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL |
| 5 mM | 0.0668 mL | 0.3341 mL | 0.6681 mL |
| 10 mM | 0.0334 mL | 0.167 mL | 0.3341 mL |
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Quality Control & SDS
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- Purity: >98.00%
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Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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