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CU-CPT-9b (TLR8-specific antagonist 1)

Catalog No.GC31729

CU-CPT-9b (TLR8-specific antagonist 1) is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

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CU-CPT-9b (TLR8-specific antagonist 1) Chemical Structure

Cas No.: 2162962-69-6

Size Price Stock Qty
10mM (in 1mL DMSO)
$151.00
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5mg
$138.00
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10mg
$220.00
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50mg
$689.00
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100mg
$1,103.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT-9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT-9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT-9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT-9b as compared to TLR8/CU-CPT8m[1].

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

Chemical Properties

Cas No. 2162962-69-6 SDF
Canonical SMILES OC1=C(C)C=C(C=C1)C2=CC=NC3=CC(O)=CC=C32
Formula C16H13NO2 M.Wt 251.28
Solubility DMSO : 100 mg/mL (397.96 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.9796 mL 19.8981 mL 39.7962 mL
5 mM 0.7959 mL 3.9796 mL 7.9592 mL
10 mM 0.398 mL 1.9898 mL 3.9796 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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