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CYN 154806

Catalog No.GC14747

somatostatin sst2 receptor antagonist

Products are for research use only. Not for human use. We do not sell to patients.

CYN 154806 Chemical Structure

Cas No.: 183658-72-2

Size Price Stock Qty
1mg
$353.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2].

References:
[1]. Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.
[2]. Feniuk W, et al. Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39(8):1443-50.

Chemical Properties

Cas No. 183658-72-2 SDF
Chemical Name (4R,4Z,5Z,7S,8Z,10S,11Z,13R,14Z,16S,17Z,19S)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-6,9,12,15,18-pentahydroxy-19-((Z)-((S)-1-hydroxy-2-((Z)-(1-hydroxyethylidene)amino)-3-(4-nitrophenyl)propylidene)amino)-N-((R)-1-hydroxy-3-(4-hydroxyphenyl)-1-iminop
Canonical SMILES C[C@](O)([H])[C@@]1([H])/C(O)=N/[C@@](/C(O)=N/[C@](C(O)=N)([H])CC2=CC=C(O)C=C2)([H])CSSC[C@](/N=C(O)/[C@](/N=C(O)/C)([H])CC3=CC=C(N(=O)=O)C=C3)([H])/C(O)=N/[C@@](/C(O)=N/[C@](/C(O)=N/[C@@](/C(O)=N/1)([H])CCCCN)([H])CC4=CNC5=CC=CC=C45)([H])CC6=CC=C(O)C=C6
Formula C56H68N12O14S2 M.Wt 1197.35
Solubility Soluble to 1 mg/ml in Water Storage Desiccate at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.8352 mL 4.1759 mL 8.3518 mL
5 mM 0.167 mL 0.8352 mL 1.6704 mL
10 mM 0.0835 mL 0.4176 mL 0.8352 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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