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D-α-Hydroxyglutaric Acid

Catalog No.: GC18583

Over-produced in the human neurometabolic disease D-2-HGA

D-α-Hydroxyglutaric Acid Chemical Structure

Size Price Stock Qty
10mg
$49.00
In stock
25mg
$93.00
In stock
50mg
$124.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

D-α-Hydroxyglutaric acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

Chemical Properties

Cas No. 13095-47-1 SDF
Synonyms N/A
Chemical Name 2R-hydroxy-pentanedioic acid
Canonical SMILES OC([C@@H](CCC(O)=O)O)=O
Formula C5H8O5 M.Wt 148.1
Solubility 75mg/mL in Water (Need ultrasonic); Insoluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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