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D-Glucosamine-2-sulfate (sodium salt)

Catalog No.GC43432

D-Glucosamine-2-sulfate (sodium salt) is an endogenous metabolite.

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D-Glucosamine-2-sulfate (sodium salt) Chemical Structure

Cas No.: 38899-05-7

Size Price Stock Qty
1g
$44.00
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5g
$198.00
In stock
10g
$374.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

D-Glucosamine-2-sulfate (GlcN-2S), a sulfate derivative of glucosamine, is derived from chitin and has anti-inflammatory effects. In vitro, it reduces expression of inflammatory markers, including IL-1β, COX-2, IL-6, and TNF-α in IL-1β-activated human chondrosarcoma SW1353 cells at a minimum effective concentration of 1 μM. At the same concentration, it limits expression of matrix metalloproteinase-3 (MMP-3) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), both markers of matrix degradation. Treating human primary chondrocytes with GlcN-2S stimulates proteoglycan production at a dose of 10 μg/mL and adhesion to fibronectin at a concentration of 50 μM.

Chemical Properties

Cas No. 38899-05-7 SDF
Canonical SMILES O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NS([O-])(=O)=O)C=O.[Na+]
Formula C6H12NO8S•Na M.Wt 281.2
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.5562 mL 17.7809 mL 35.5619 mL
5 mM 0.7112 mL 3.5562 mL 7.1124 mL
10 mM 0.3556 mL 1.7781 mL 3.5562 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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