Dabigatran Acyl-β-D-Glucuronide (Synonyms: β-1-O-Acylglucuronide) |
| Catalog No.GC43371 |
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1015167-40-4
Sample solution is provided at 25 µL, 10mM.
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Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.
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