Dapagliflozin-3-O-β-D-Glucuronide |
| Catalog No.GC43376 |
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1351438-75-9
Sample solution is provided at 25 µL, 10mM.
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Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]
Reference:
[1]. Chao, E.C., and Henry, R.R. SGLT2 inhibition - A novel strategy for diabetes treatment. Nature Reviews.Drug Discovery 9(7), 551-559 (2010).
[2]. van der Walt, J.-S., Hong, Y., Zhang, L., et al. A nonlinear mixed effects pharmacokinetic model for dapagliflozin and dapagliflozin 3-O-glucuronide in renal or hepatic impairment. CPT Pharmacometrics Syst. Pharmacol. 2(e42), 1-9 (2013)
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