Startseite>>Signaling Pathways>> DNA Damage/DNA Repair>> DNA Alkylating>>1-Ethyl-1-nitrosourea (hydrate)

1-Ethyl-1-nitrosourea (hydrate) (Synonyms: ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea)

Katalog-Nr.GC49470

A DNA alkylating agent

Products are for research use only. Not for human use. We do not sell to patients.

1-Ethyl-1-nitrosourea (hydrate) Chemische Struktur

Cas No.: N/A

Größe Preis Lagerbestand Menge
1 g
46,00 $
Auf Lager
5 g
162,00 $
Auf Lager
10 g
301,00 $
Auf Lager
25 g
633,00 $
Auf Lager

Tel:(909) 407-4943 Email: sales@glpbio.com

Kundenbewertungen

Basiert auf Kundenrezensionen.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.1 It increases the concentrations of O6-ethylguanine, N7-ethylguanine, N7-ethyladenine, and N3-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenic in vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.2

1.Goth, R., and Rajewsky, M.F.Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosoureaProc. Natl. Acad. Sci. USA71(3)639-643(1974) 2.Druckrey, H., Ivankovi?, S., and Preussmann, R.Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant ratsNature210(5043)1378-1379(1966)

Chemical Properties

Cas No. N/A SDF Download SDF
Überlieferungen ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea
Canonical SMILES O=NN(CC)C(N)=O
Formula C3H7N3O2 • XH2O M.Wt 117.1
Löslichkeit DMF: 15 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL,PBS (pH 7.2): 3 mg/mL Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 8.5397 mL 42.6985 mL 85.3971 mL
5 mM 1.7079 mL 8.5397 mL 17.0794 mL
10 mM 0.854 mL 4.2699 mL 8.5397 mL
  • Molaritätsrechner

  • Verdünnung-Rechner

Gewicht
=
Konzentration
x
Inhalt
x
MW*
 
 
 
**Bei der Herstellung von Stammlösungen ist immer das chargenspezifische Molekulargewicht von

Berechnen

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Bewertungen

Review for 1-Ethyl-1-nitrosourea (hydrate)

Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for 1-Ethyl-1-nitrosourea (hydrate)

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.