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1-Ethynylnaphthalene

Katalog-Nr.GC33073

1-Ethynylnaphthalin ist ein selektiver Inhibitor von Cytochrom P450 1B1.

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1-Ethynylnaphthalene Chemische Struktur

Cas No.: 15727-65-8

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10mM (in 1mL DMSO)
50,00 $
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100mg
46,00 $
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500mg
92,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.

1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].

[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.

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