1-Naphthohydroxamic acid |
| Katalog-Nr.GC39214 |
1-NaphthohydroxamsÄure (Verbindung 2) ist ein potenter und selektiver HDAC8-Inhibitor mit einem IC50 von 14 μM. 1-NaphthohydroxamsÄure ist selektiver fÜr HDAC8 als Klasse-I-HDAC1 und Klasse-II-HDAC6 (IC50 > 100 μM). 1-NaphthohydroxamsÄure erhÖht die globale Histon-H4-Acetylierung nicht und verringert auch nicht die intrazellulÄre HDAC-GesamtaktivitÄt. 1-NaphthohydroxamsÄure kann die Tubulinacetylierung induzieren.
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Cas No.: 6953-61-3
Sample solution is provided at 25 µL, 10mM.
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1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.
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