1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (Synonyms: 15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11) |
Katalog-Nr.GC49730 |
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
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Sample solution is provided at 25 µL, 10mM.
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 is intended for use as an internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE by GC- or LC-MS. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO).1,2 Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.
1.Maskrey, B.H., BermÚdez-Fajardo, A., Morgan, A.H., et al.Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenaseJ. Biol. Chem.282(28)20151-20163(2007) 2.Morgan, A.H., Hammond, V.J., Morgan, L., et al.Quantitative assays for esterified oxylipins generated by immune cellsNat. Protoc.5(12)1919-1931(2010)
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