10-acetyl Docetaxel (Synonyms: PNU 101383, 10-acetyl Taxotere) |
| Katalog-Nr.GC49736 |
10-Acetyl-Docetaxel (10-Acetyl-Docetaxel) ist ein Analogon von Docetaxel mit AntikrebsaktivitÄt. Docetaxel ist ein Inhibitor der Mikrotubuli-Zerlegung mit antimitotischer AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125354-16-7
Sample solution is provided at 25 µL, 10mM.
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10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1 It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 µM. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50 = 0.05 µM).
1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)
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