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10-Nitrooleate (Synonyms: 10Nitrooleic Acid, 10nitro9transOctadecenoic Acid)

Katalog-Nr.GC41868

10-Nitrooleat (CXA-10), eine NitrofettsÄure, hat potenzielle Wirkungen bei KrankheitszustÄnden, bei denen oxidativer Stress, EntzÜndungen, Fibrose und/oder direkte GewebetoxizitÄt eine bedeutende Rolle spielen.

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10-Nitrooleate Chemische Struktur

Cas No.: 875685-46-4

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.

Chemical Properties

Cas No. 875685-46-4 SDF
Überlieferungen 10Nitrooleic Acid, 10nitro9transOctadecenoic Acid
Canonical SMILES CCCCCCCC/C([N+]([O-])=O)=C\CCCCCCCC(O)=O
Formula C18H33NO4 M.Wt 327.5
Löslichkeit Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.0534 mL 15.2672 mL 30.5344 mL
5 mM 0.6107 mL 3.0534 mL 6.1069 mL
10 mM 0.3053 mL 1.5267 mL 3.0534 mL
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