15-Acetyldeoxy Nivalenol (Synonyms: 15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate) |
| Katalog-Nr.GC19442 |
15-Acetyldeoxy-Nivalenol ist ein hochgiftiges Trichothecen, das in Getreide vorkommt, und ein Metabolit von Deoxynivalenol, der für HepG2-Zellen toxisch ist.
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Cas No.: 88337-96-6
Sample solution is provided at 25 µL, 10mM.
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15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops. It is an acetylated derivative of 4-deoxy nivalenol that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration. It also changes brain bioamine neurotransmitter levels in pigs and chickens.
References:
[1].Ajandouz, E.H., Berdah, S., Moutardier, V., et al. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: Specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches Toxins (Basel) 8(8), E232 (2016).
[2]. Pestka, J.J., Lin, W.-S., and Miller, E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine Food Chem. Toxicol. 25(11), 855-888 (1987).
[3].Payros, D., Alazzane-Kpembi, I., Pierron, A., et al. Toxicology of deoxynivalenol and its acetylated and modified forms Arch. Toxicol. 90(12), 2931-2957 (2016).
[4].Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target Toxins (Basel) 4(11), 1120-1138 (2012).
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