18-hydroxy-11-deoxy Corticosterone (Synonyms: 18-Hydroxydeoxycorticosterone, 18-OH-DOC) |
| Katalog-Nr.GC18635 |
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 379-68-0
Sample solution is provided at 25 µL, 10mM.
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18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
References:
[1].Braley, L.M., and Williams, G.H. The effect of angiotensin II and saralasin on 18-hydroxy-ll-deoxycorticosterone production by isolated human adrenal glomerulosa cells J. Clin. Endocrinol. Metab. 49(4), 600-603 (1979).
[2].Carroll, J.C., Komanicky, P., and Melby, J.C. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat J. Steroid Biochem. 14(10), 989-995 (1981).
[3].Müller, J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: Evidence for an alternative biosynthetic pathway J. Steroid Biochem. 13(3), 245-251 (1980).
[4].Slominski, A., Gomez-Sanchez, C.E., Foecking, M.F., et al. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells FEBS Lett. 455(3), 364-366 (1999).
[5]. Giesbertz, P., Padberg, I., Rein, D., et al. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes Diabetologia 58(9), 2133-2143 (2015).
| Cas No. | 379-68-0 | SDF | |
| Überlieferungen | 18-Hydroxydeoxycorticosterone, 18-OH-DOC | ||
| Chemical Name | 18,21-dihydroxy-pregn-4-ene-3,20-dione | ||
| Canonical SMILES | O=C(CO)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@@]21CO)=O | ||
| Formula | C21H30O4 | M.Wt | 346.5 |
| Löslichkeit | DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.886 mL | 14.43 mL | 28.86 mL |
| 5 mM | 0.5772 mL | 2.886 mL | 5.772 mL |
| 10 mM | 0.2886 mL | 1.443 mL | 2.886 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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