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19,20-Epoxycytochalasin D

Katalog-Nr.GC41983

19,20-Epoxycytochalasin D, ein Cytochalasin, ist ein Pilzmetabolit von Nemania sp.

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19,20-Epoxycytochalasin D Chemische Struktur

Cas No.: 191349-10-7

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.

Chemical Properties

Cas No. 191349-10-7 SDF
Canonical SMILES O=C1[C@@](O)(C)[C@H](O2)[C@@H]2[C@@H](OC(C)=O)[C@]3([C@](/C=C/C[C@@H]1C)([H])[C@@H]4O)[C@@]([C@H](CC5=CC=CC=C5)NC3=O)([H])[C@H](C)C4=C
Formula C30H37NO7 M.Wt 523.6
Löslichkeit DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5493 mL 19.0985 mL
5 mM 0.382 mL 1.9099 mL 3.8197 mL
10 mM 0.191 mL 0.9549 mL 1.9099 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Bewertungen

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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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