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21-Deoxycortisone (Synonyms: 21-Desoxycortisone, NSC 38722)

Katalog-Nr.GC52083

A corticosteroid metabolite of 11-keto progesterone

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21-Deoxycortisone Chemische Struktur

Cas No.: 1882-82-2

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone.1 It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be produced via oxidation of 21-deoxycortisol by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.2

1.van Rooyen, D., Yadav, R., Scott, E.E., et al.CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathwayJ. Steroid Biochem. Mol. Biol.199105614(2020) 2.Saisho, S., Shimozawa, K., and Yata, J.Changes of several adrenal δ4-steroids measured by HPLC-UV spectrometry in neonatal patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiencyHorm. Res.33(1)27-34(1990)

Chemical Properties

Cas No. 1882-82-2 SDF Download SDF
Überlieferungen 21-Desoxycortisone, NSC 38722
Canonical SMILES C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
Formula C21H28O4 M.Wt 344.5
Löslichkeit DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9028 mL 14.5138 mL 29.0276 mL
5 mM 0.5806 mL 2.9028 mL 5.8055 mL
10 mM 0.2903 mL 1.4514 mL 2.9028 mL
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