(2R,3R)-E1R |
| Katalog-Nr.GC38712 |
(2R,3R)-E1R (Verbindung 2b) ist ein Enantiomer von E1R.
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Cas No.: 1400888-63-2
Sample solution is provided at 25 µL, 10mM.
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(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].
Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1].
[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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