3,3',5-Triiodo-L-thyronine (sodium salt hydrate) (Synonyms: Liothyronine, T3, L3,3',5Triiodothyronine) |
| Katalog-Nr.GC48395 |
3,3',5-Triiod-L-thyronin (Natriumsalzhydrat) ist eine aktive Form des SchilddrÜsenhormons.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 345957-19-9
Sample solution is provided at 25 µL, 10mM.
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3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone.1 It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling.2,3,4,5 It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.6
1.Larsen, P.R., Silva, J.E., and Kaplan, M.M.Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implicationsEndocr. Rev.2(1)87-102(1981) 2.Shiohara, H., Nakamura, T., Kikuchi, N., et al.Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemiaBioorgan. Med. Chem.20(11)3622-3634(2012) 3.Cox, M.D., Dalal, S.S., Heard, C.R.C., et al.Metabolic rate and thyroid status in rats fed diets of different protein-energy value: The importance of free T3J. Nutri.114(9)1609-1616(1984) 4.Macchia, P.E., Takeuchi, Y., Kawai, T., et al.Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor αProc. Nat. Acad. Sci. U.S.A.98(1)349-354(2001) 5.Videla, L.A., Cornejo, P., Romanque, P., et al.Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioningSci. World J.20121-11(2012) 6.Kongpracha, P., Nagamori, S., Wiriyasermkul, P., et al.Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)J. Pharmacol. Sci.133(2)96-102(2017)
| Cas No. | 345957-19-9 | SDF | |
| Überlieferungen | Liothyronine, T3, L3,3',5Triiodothyronine | ||
| Canonical SMILES | IC1=C(OC2=CC(I)=C(O)C=C2)C(I)=CC(C[C@@H](C([O-])=O)N)=C1.[Na+].O | ||
| Formula | C15H11I3NO4•Na [XH2O] | M.Wt | 673 |
| Löslichkeit | DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4859 mL | 7.4294 mL | 14.8588 mL |
| 5 mM | 0.2972 mL | 1.4859 mL | 2.9718 mL |
| 10 mM | 0.1486 mL | 0.7429 mL | 1.4859 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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