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3,5-Diiodothyropropionic Acid (Synonyms: DITPA)

Katalog-Nr.GC18696

3,5-DiiodthyropropionsÄure ist ein SchilddrÜsenhormonanalogon, induziert die mRNA-Expression der schweren Kette von α-Myosin, bindet an den SchilddrÜsenhormonrezeptor (TR), mit Ka von 2,40 und 4,06 M-1 fÜr TRα1 bzw. TRβ1 .

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3,5-Diiodothyropropionic Acid Chemische Struktur

Cas No.: 1158-10-7

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).1 DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.2 DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.3 It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.4

Chemical Properties

Cas No. 1158-10-7 SDF
Überlieferungen DITPA
Chemical Name 4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanoic acid
Canonical SMILES IC1=CC(CCC(O)=O)=CC(I)=C1OC2=CC=C(O)C=C2
Formula C15H12I2O4 M.Wt 510.1
Löslichkeit DMSO: Slightly Soluble,Methanol: Slightly Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.9604 mL 9.802 mL 19.604 mL
5 mM 0.3921 mL 1.9604 mL 3.9208 mL
10 mM 0.196 mL 0.9802 mL 1.9604 mL
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