3,6-DMAD hydrochloride |
Katalog-Nr.GC34384 |
3,6-DMAD-Hydrochlorid, ein Acridin-Derivat, ist ein potenter Inhibitor des IRE1α-XBP1s-Signalwegs. 3,6-DMAD-Hydrochlorid fÖrdert die IL-6-Sekretion Über den IRE1α-XBP1s-Weg. 3,6-DMAD-Hydrochlorid hemmt die Oligomerisierung von IRE1α und die AktivitÄt von Endoribonuclease (RNase). 3,6-DMAD-Hydrochlorid kann fÜr die Krebsforschung verwendet werden.
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Sample solution is provided at 25 µL, 10mM.
3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.
3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity[1].
Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth[1].
[1]. Jiang D, et al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65.
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