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3-Hydroxy Midostaurin (Synonyms: CGP52421)

Katalog-Nr.GC39689

3-Hydroxy-Midostaurin (CGP 52421), ein Metabolit von PKC412, hemmt wirksam die Autophosphorylierung der FMS-Ähnlichen Tyrosinkinase-3 (FLT3) mit IC50-Werten von etwa 132 nM bzw. 9,8 μM in Kulturmedium bzw. Plasma. 3-Hydroxy-Midostaurin ist weniger selektiv, aber zytotoxischer als PKC412.

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3-Hydroxy Midostaurin Chemische Struktur

Cas No.: 179237-49-1

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.

Chemical Properties

Cas No. 179237-49-1 SDF
Überlieferungen CGP52421
Canonical SMILES OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O
Formula C35H30N4O5 M.Wt 586.64
Löslichkeit Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.7046 mL 8.5231 mL 17.0462 mL
5 mM 0.3409 mL 1.7046 mL 3.4092 mL
10 mM 0.1705 mL 0.8523 mL 1.7046 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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