653-47 hydrochloride |
| Katalog-Nr.GC62144 |
653-47-Hydrochlorid, ein Potentiator, potenziert die HemmaktivitÄt des cAMP-Response-Element-Bindungsproteins (CREB) von 666-15 signifikant. 653-47 Hydrochlorid ist auch ein sehr schwacher CREB-Inhibitor mit IC50 von 26,3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1224567-46-7
Sample solution is provided at 25 µL, 10mM.
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653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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