7-oxo Staurosporine (Synonyms: BMY 41950, RK-1409) |
| Katalog-Nr.GC42616 |
7-oxo Staurosporine is an antibiotic originally isolated from S.
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Cas No.: 125035-83-8
Sample solution is provided at 25 µL, 10mM.
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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