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α-Ecdysone

Katalog-Nr.GC45204

α-Ecdyson ist ein Prohormon von 20-Hydroxy-Ecdyson, einem Insekten-Molting-, Ecdysteroid-Hormon.

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α-Ecdysone Chemische Struktur

Cas No.: 3604-87-3

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Ecdyson ist ein Prohormon von 20-Hydroxy-Ecdyson, einem Insekten-Mauser-, Ecdysteroid-Hormon. Das Insekt-Neurohormon, das prothorakotrope Hormon, stimuliert die Prothorakaldrüsen zur Freisetzung von α-Ecdyson, das dann schnell in sein aktives Metabolit 20-Hydroxy-Ecdyson umgewandelt wird.

References:

[1]. Fallon, A.M., and Gerenday, A. Ecdysone and the cell cycle: Investigations in a mosquito cell line. J.Insect Physiol. 56(10), 1396-1401 (2010).
[2]. Carrow, G.M., Calabrese, R.L., and Williams, C.M. Spontaneous and evoked release of prothoracicotropin from multiple neurohemal organs of the tobacco hornworm. Proceedings of the National Academy of Sciences of the United States of America 78(9), 5866-5870 (1981).
[3]. Cherbas, L., and Cherbas, P. Distribution and metabolism of α-ecdysone in pupae of the silkworm Antheraea Polyphemus. Biol.Bull. 138(2), 115-128 (1970).

Chemical Properties

Cas No. 3604-87-3 SDF
Chemical Name (5β)-2β,3β,14,22R,25-pentahydroxy-cholest-7-en-6-one
Canonical SMILES O=C1[C@]2([H])C[C@@H](O)[C@@H](O)C[C@]2(C)[C@]3([H])C([C@@](CC[C@@H]4[C@H](C)[C@H](O)CCC(C)(O)C)(O)[C@]4(C)CC3)=C1
Formula C27H44O6 M.Wt 464.6
Löslichkeit DMF: 2 mg/mL,DMSO: 0.1 mg/mL,Ethanol: 20 mg/mL,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1524 mL 10.7619 mL 21.5239 mL
5 mM 0.4305 mL 2.1524 mL 4.3048 mL
10 mM 0.2152 mL 1.0762 mL 2.1524 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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