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α-GalCer analog 8 (Synonyms: α-Galactosylceramide analog 8)

Katalog-Nr.GC45206

α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.

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α-GalCer analog 8 Chemische Struktur

Cas No.: 922727-14-8

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1mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.

Reference:
[1]. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer. J. Med. Chem. 50(3), 585-589 (2007).

Chemical Properties

Cas No. 922727-14-8 SDF
Überlieferungen α-Galactosylceramide analog 8
Canonical SMILES O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)([H])N2N=NC(CCCCCCCCCCCCCCCCCCCCCCCC)=C2
Formula C50H97N3O8 M.Wt 868.3
Löslichkeit Soluble in DMSO, Soluble in DMF, Soluble in Ethanol, Soluble in Methanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.1517 mL 5.7584 mL 11.5168 mL
5 mM 0.2303 mL 1.1517 mL 2.3034 mL
10 mM 0.1152 mL 0.5758 mL 1.1517 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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