γ-Glu-Phe (trifluoroacetate salt) (Synonyms: γ-Glutamylphenylalanine) |
| Katalog-Nr.GC52404 |
A dipeptide with metabolism-altering activity
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
γ-Glu-Phe is an endogenous dipeptide that is composed of L-glutamic acid and L-phenylalanine and has also been found in Allium.1 It prevents increases in lipid accumulation in AML12 hepatocytes stimulated with oleic acid when used at a concentration of 30 µM. γ-Glu-Phe (2.5-10 mM) increases levels of the calcium-sensing receptor (CaSR) and secretion of cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) in STC-1 enteroendocrine cells.2 Changes in urine levels of γ-Glu-Phe are associated with hypertension and phenylketonuria (PKU) and changes in serum levels are associated with prostate cancer.3,4,5
1.Lee, Y.G., Cho, J.-Y., Hwang, E.J., et al.Glu-Phe from onion (Allium Cepa L.) attenuates lipogenesis in hepatocytesBiosci. Biotech. Biochem.81(7)1409-1416(2017) 2.Yang, J., Bai, W., Zeng, X., et al.γ-[Glu](n=1,2)-Phe/-Met/-Val stimulates gastrointestinal hormone (CCK and GLP-1) secretion by activating the calcium-sensing receptorFood Funct.10(7)4071-4080(2019) 3.Shi, M., He, J., Li, C., et al.Metabolomics study of blood pressure salt-sensitivity and hypertensionNutr. Metab. Cardiovasc. Dis.32(7)1681-1692(2022) 4.Peck, H., and Pollitt, R.J.The occurrence of γ-glutamylphenylalanine in the urine of newborn phenylketonuricsClin. Chim. Acta94(3)237-240(1979) 5.Huang, J., Mondul, A.M., Weinstein, S.J., et al.Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trialBr. J. Cancer115(9)1087-1095(2016)
| Cas No. | SDF | ||
| Überlieferungen | γ-Glutamylphenylalanine | ||
| Canonical SMILES | OC([C@@H](NC(CC[C@H](N)C(O)=O)=O)CC1=CC=CC=C1)=O.OC(C(F)(F)F)=O | ||
| Formula | C14H18N2O5 ? XCF3COOH | M.Wt | 294.3 |
| Löslichkeit | DMF: 2 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3979 mL | 16.9895 mL | 33.9789 mL |
| 5 mM | 0.6796 mL | 3.3979 mL | 6.7958 mL |
| 10 mM | 0.3398 mL | 1.6989 mL | 3.3979 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *