δ12-Prostaglandin J2 (Synonyms: Δ12PGJ2) |
| Katalog-Nr.GC41109 |
δ12-Prostaglandin J2 (δ12-PGJ2) ist ein Cyclopentenon-Prostaglandin (PG) mit antiproliferativer Wirkung auf verschiedenes Tumorzellwachstum. δ12-Prostaglandin J2, ein natÜrlich vorkommendes Dehydratisierungsprodukt von Prostaglandin D2, kann Über Caspase-Aktivierung Apoptose in HeLa-Zellen induzieren.
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Cas No.: 87893-54-7
Sample solution is provided at 25 µL, 10mM.
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δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml. δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.
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