Ac-FLTD-CMK (trifluoroacetate salt) (Synonyms: Ac-Phe-Leu-Thr-Asp-CMK) |
| Katalog-Nr.GC49704 |
An inhibitor of caspase-1, -4, -5, and -11
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Ac-FLTD-CMK is an inhibitor of caspase-1, -4, -5, and -11.1 It inhibits caspase-1, -4, and -5 (IC50s = 0.0467, 1.49, and 0.329, respectively, for the recombinant human enzymes) and cleavage of gasdermin D (GSDMD), an effector involved in pyroptosis and NETosis, by mouse caspase-11 when used at a concentration of 10 µM. Ac-FLTD-CMK (10 µM) inhibits LPS- and ATP- or LPS- and nigericin-induced pyroptosis and IL-1β release in mouse bone marrow-derived macrophages (BMDMs).
1.Yang, J., Liu, Z., Wang, C., et al.Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitorProc. Natl. Acad. Sci. USA115(26)6792-6797(2018)
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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