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Ac-LEHD-AMC (trifluoroacetate salt) (Synonyms: Ac-Leu-Glu-His-Asp-AMC, Caspase-9 Substrate)

Katalog-Nr.GC18226

Ac-LEHD-AMC (Trifluoracetatsalz) ist ein fluorogenes Substrat fÜr Caspase-9 (Anregung: 341 nm; Emission: 441 nm).

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Ac-LEHD-AMC (trifluoroacetate salt) Chemische Struktur

Cas No.: 292633-16-0

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.[1]  Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

References
[1]. Prudnikov, I.M., and Smirnov, A.N. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: An approach for the differential identification of proteases. J. Biochem. 151(3), 299-316 (2012).

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