AMG 853 (Synonyms: AMG 853) |
| Katalog-Nr.GC50240 |
AMG 853 (AMG 853) ist ein PhenylessigsÄurederivat.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1169483-24-2
Sample solution is provided at 25 µL, 10mM.
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Potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.
Liu et al (2011) Discovery of AMG 853, a CRTH2 and DP dual antagonist. ACS Med.Chem.Lett. 2 326 PMID:24900313
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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