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Antennapedia Peptide

Katalog-Nr.GC33336

Das Antennapedia-Peptid ist ein 16 AminosÄuren langes Peptid, das ursprÜnglich aus der 60 AminosÄuren langen HomÖodomÄne des Drosophila-Transkriptionsfaktors Antennapedia stammt und ein Mitglied der Familie der zellpenetrierenden Peptide ist.

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Antennapedia Peptide Chemische Struktur

Cas No.: 188842-14-0

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.

Antennapedia (Antp)-SMCC-cytochrome c conjugate (5 μg/mL) activates caspase-dependent apoptosis of HeLa cells. The Antp-SMCC-cytochrome c conjugate reduces the clonogenic survival of Hela cells, and inhibits clonogenic survival[1]. ANTP-SmacN7 fusion protein can transduce and accumulate in cells, while SmacN7 alone cannot. ANTP-SmacN7 fusion proteins have a radiation-sensitising effect on EC109 cells. ANTP-SmacN7 combined with radiation does not promote further increases in caspase-3 protein expression, it increases the levels of cleaved caspase-3[2].

[1]. Imesch P, et al. Conjugates of cytochrome c and antennapedia peptide activate apoptosis and inhibit proliferation of HeLa cancer cells. Exp Ther Med. 2013 Sep;6(3):786-790. Epub 2013 Jul 4. [2]. Du LQ, et al. Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells. Int J Mol Sci. 2013 Dec 11;14(12):24087-96.

Chemical Properties

Cas No. 188842-14-0 SDF
Canonical SMILES Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys
Formula C104H168N34O20S M.Wt 2246.8
Löslichkeit Soluble in Water Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.4451 mL 2.2254 mL 4.4508 mL
5 mM 0.089 mL 0.4451 mL 0.8902 mL
10 mM 0.0445 mL 0.2225 mL 0.4451 mL
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