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B-Raf IN 10

Katalog-Nr.GC65978

B-Raf IN 10 (Compound C09) ist ein BRAF-Inhibitor mit einem IC50 zwischen 50 und 100 nM. B-Raf IN 10 zeigt AntitumoraktivitÄt.

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B-Raf IN 10 Chemische Struktur

Cas No.: 1425485-87-5

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1].
B-Raf IN 10 shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1].

Cell Viability Assay[1]

Cell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1
Concentration:
Incubation Time: 72 h
Result: Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

Chemical Properties

Cas No. 1425485-87-5 SDF Download SDF
Formula C22H21F3N4O4S M.Wt 494.49
Löslichkeit DMSO : 100 mg/mL (202.23 mM; ultrasonic and warming and heat to 60°C) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0223 mL 10.1114 mL 20.2229 mL
5 mM 0.4045 mL 2.0223 mL 4.0446 mL
10 mM 0.2022 mL 1.0111 mL 2.0223 mL
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