β-Casomorphin, bovine (β-Casomorphin-7 (bovine)) |
| Katalog-Nr.GC33736 |
β-Casomorphin, Rind (β-Casomorphin-7 (Rind)) (⋲-Casomorphin-7 (Rind) ) ist ein Opioid-Peptid mit einem IC50 von 14 μM in einem Opioidrezeptor-Bindungsassay.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72122-62-4
Sample solution is provided at 25 µL, 10mM.
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β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
β-casomorphin(β-casomorphin-7) strongly stimulates mucin secretion in the rat jejunum through a nervous pathway and opioid receptor activation. In rat DHE cells, β-casomorphin(β-casomorphin-7) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC. In human HT29-MTX cells, β-casomorphin(β-casomorphin-7) also increases MUC5AC mRNA levels (219% after 24 h of stimulation) and the secretion of this mucin. β-casomorphin(β-casomorphin-7) may contribute significantly to mucin production via a direct effect on intestinal goblet cells and the activation of -opioid receptors[2].
Oral administration of β-casomorphin(β-casomorphin-7) for 30 days to rats with STZ-induced diabetes results in a significant increase in serum level of insulin, and a decrease in the level of glucagon. The administration of β-casomorphin(β-casomorphin-7) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-casomorphin(β-casomorphin-7) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].
[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.
| Cas No. | 72122-62-4 | SDF | |
| Canonical SMILES | Tyr-Pro-Phe-Pro-Gly-Pro-Ile | ||
| Formula | C41H55N7O9 | M.Wt | 789.92 |
| Löslichkeit | DMSO : 100 mg/mL (126.60 mM; Need ultrasonic); H2O : ≥ 50 mg/mL (63.30 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.266 mL | 6.3298 mL | 12.6595 mL |
| 5 mM | 0.2532 mL | 1.266 mL | 2.5319 mL |
| 10 mM | 0.1266 mL | 0.633 mL | 1.266 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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