BTSA1 |
| Katalog-Nr.GC39355 |
BTSA1 ist ein potenter, hochaffiner und oral aktiver BAX-Aktivator mit einem IC50 von 250 nM und einem EC50 von 144 nM. BTSA1 bindet mit hoher AffinitÄt und SpezifitÄt an die N-terminale Aktivierungsstelle und induziert KonformationsÄnderungen an BAX, die zu BAX-vermittelter Apoptose fÜhren.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 314761-14-3
Sample solution is provided at 25 µL, 10mM.
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BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
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