Bupropion hydrochloride (Synonyms: NSC 315851) |
| Katalog-Nr.GC14714 |
Dopamine/norepinephrine inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31677-93-7
Sample solution is provided at 25 µL, 10mM.
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Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6μM and 3.4 ± 0.4 μM, respectively [1].
Bupropion hydrochloride is an aminoketone used as non-nicotine aid to smoking cessation. Bupropion hydrochloride is also a typical antidepressant agent that interferes with norepinephrine, serotonin, and dopamine reuptake [2]. In addition, Bupropion hydrochloride has been reported to reduce the expression of tyrosine hydroxylase, a rate-limiting enzyme in dopamine biosynthesis [3]. In vitro, it has been shown that Bupropion hydrochloride can decrease cell viability significantly in SH-SY5Y cells. Furthermore, Bupropion hydrochloride has been revealed to selectively activate an ER stress pathway. Apart from these, the result has also shown that Bupropion hydrochloride can induce cell death as a result of caspase 3 activation through the JNK and ER stress [2].
References:
[1] Dr. R. M. Ferris*, H. L. White,B. R. Cooper, R. A. Maxwell, F. L. M. Tang,O. J. Beaman and A. Russell .Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin™). Drug Development Research Volume 1, Issue 1, pages 21–35, 1981
[2] Jang EH1, Park CS, Kang JH. Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. Toxicology. 2011 Jul 11;285(1-2):1-7.
[3] Nestler, E.J., McMahon, A., Sabban, E.L., Tallman, J.F., Duman, R.S., 1990. Chronicantidepressant administration decreases the expression of tyrosine hydroxylase
in the rat locus coeruleus. Proc. Natl. Acad. Sci. U. S. A. 87, 7522–7526.
| Cas No. | 31677-93-7 | SDF | |
| Überlieferungen | NSC 315851 | ||
| Chemical Name | 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride | ||
| Canonical SMILES | CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl | ||
| Formula | C13H19Cl2NO | M.Wt | 276.2 |
| Löslichkeit | ≥ 12.85mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6206 mL | 18.1028 mL | 36.2056 mL |
| 5 mM | 724.1 μL | 3.6206 mL | 7.2411 mL |
| 10 mM | 362.1 μL | 1.8103 mL | 3.6206 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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