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Carisbamate (Synonyms: JNJ10234094, RWJ 333369)

Katalog-Nr.GC18505

Carisbamat (RWJ-333369) ist ein oral aktiver Neuromodulator.

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Carisbamate Chemische Struktur

Cas No.: 194085-75-1

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Sample solution is provided at 25 µL, 10mM.

Description of Carisbamate

Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.

Chemical Properties of Carisbamate

Cas No. 194085-75-1 SDF
Überlieferungen JNJ10234094, RWJ 333369
Chemical Name (1S)-1-(2-chlorophenyl)-1,2-ethanediol, 2-carbamate
Canonical SMILES ClC1=C([C@H](O)COC(N)=O)C=CC=C1
Formula C9H10ClNO3 M.Wt 215.6
Löslichkeit DMSO : ≥ 100 mg/mL (463.76 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Carisbamate

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.6382 mL 23.1911 mL 46.3822 mL
5 mM 927.6 μL 4.6382 mL 9.2764 mL
10 mM 463.8 μL 2.3191 mL 4.6382 mL
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In vivo Formulation Calculator (Clear solution) of Carisbamate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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