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(S)-CR8

Katalog-Nr.GC46351

(S)-CR8 ist das S-Isomer von CR8. (S)-CR8 ist ein potenter und selektiver CDK-Inhibitor mit IC50-Werten von 0,060, 0,080, 0,11, 0,12 und 0,15 μM fÜr CDK2/Cyclin E, CDK2/Cyclin A, CDK9/Cyclin T, CDK5/p25 und CDK1/Cyclin B bzw. (S)-CR8 reduziert das Überleben von SH-SY5Y-Zellen (IC50 0,40 μM).

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(S)-CR8 Chemische Struktur

Cas No.: 1084893-56-0

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1 mg
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5 mg
255,00 $
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10 mg
391,00 $
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25 mg
676,00 $
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 µM, respectively).1 It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 µM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 µM, respectively).2 It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

1.Bettayeb, K., Oumata, N., Echalier, A., et al.CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinasesOncogene27(44)5797-5807(2008) 2.Bettayeb, K., Baunbaek, D., Delehouze, C., et al.CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cellsGenes Cancer1(4)369-380(2010)

Chemical Properties

Cas No. 1084893-56-0 SDF
Canonical SMILES CC(C)N1C2=NC(N[C@H](CO)CC)=NC(NCC3=CC=C(C4=NC=CC=C4)C=C3)=C2N=C1
Formula C24H29N7O M.Wt 431.5
Löslichkeit DMSO: soluble,Ethanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.3175 mL 11.5875 mL 23.175 mL
5 mM 0.4635 mL 2.3175 mL 4.635 mL
10 mM 0.2317 mL 1.1587 mL 2.3175 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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