Startseite>>Analytical Standards>>1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC

1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC (Synonyms: 18:0/20:4-d8-PC, PC(18:0/20:4-d8), SAPCd8, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphocholine)

Katalog-Nr.GC46496

An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC

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1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC Chemische Struktur

Cas No.: 161922-50-5

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50 μg
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100 μg
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500 μg
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1 mg
1.031,00 $
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

1-Stearoyl-2-arachidonoyl-d8-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by GC- or LC-MS. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC) is a phospholipid containing stearic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and has been found in human stenotic aortic valves and atherosclerotic plaques.1,2 Levels of SAPC are increased in the subepithelial invasive region compared to the superficial region of tumor tissue samples from patients with superficial-type pharyngeal squamous cell carcinoma.3 SAPC unilamellar vesicles have been used as substrates to quantify the activity of secretory phospholipase A2 (sPLA2) in the presence or absence of inhibitors.4 SAPC has also been used in the formation of lipid bilayers to study the effects of lipid composition on bilayer phase transitions.5

1.Milne, G.L., Seal, J.R., Havrilla, C.M., et al.Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteinsJ. Lipid Res.46(2)307-319(2005) 2.Lehti, S., KÄkelÄ, R., HÖrkkÖ, S., et al.Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valvesPLoS One8(6)e65810(2013) 3.Ishikawa, S., Tateya, I., Hayasaka, T., et al.The distribution of phosphatidylcholine species in superficial-type pharyngeal carcinomaBiomed. Res. Int.5387913(2017) 4.Schebb, N.H., Falck, D., Faber, H., et al.Fast method for monitoring phospholipase A2 activity by liquid chromatography-electrospray ionization mass spectrometryJ. Chromatogr. A1216(27)5249-5255(2009) 5.Tada, K., Goto, M., Tamai, N., et al.Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chainAnn. N.Y. Acad. Sci.1189(1)77-85(2010)

Chemical Properties

Cas No. 161922-50-5 SDF
Überlieferungen 18:0/20:4-d8-PC, PC(18:0/20:4-d8), SAPCd8, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphocholine
Canonical SMILES [O-]P(OC[C@H](OC(CCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(OCC[N+](C)(C)C)=O
Formula C46H76D8NO8P M.Wt 818.2
Löslichkeit Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.2222 mL 6.111 mL 12.222 mL
5 mM 0.2444 mL 1.2222 mL 2.4444 mL
10 mM 0.1222 mL 0.6111 mL 1.2222 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Average Rating: 5 ★★★★★ (Based on Reviews and 27 reference(s) in Google Scholar.)

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