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β-Defensin-2 (human) (trifluoroacetate salt) (Synonyms: hBD-2)

Katalog-Nr.GC48298

An antimicrobial peptide

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β-Defensin-2 (human) (trifluoroacetate salt) Chemische Struktur

Cas No.: N/A

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100 μg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius.2 β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 Expression of β-defensin-2 is increased in psoriatic skin and chronic wounds.5,6

1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 3.Niyonsaba, F., Ushio, H., Nakano, N., et al.Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokinesJ. Invest. Dermatol.127(3)594-604(2007) 4.Niyonsaba, F., Ushio, H., Hara, M., et al.Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cellsJ. Immunol.184(7)3526-3534(2010) 5.Huh, W.-K., Oono, T., Shirafuji, Y., et al.Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skinJ. Mol. Med. (Berl.)80(10)678-684(2002) 6.Butmarc, J., Yufit, T., Carson, P., et al.Human β-defensin-2 expression is increased in chronic woundsWound Repair Regen.12(4)439-443(2004)

Chemical Properties

Cas No. N/A SDF
Überlieferungen hBD-2
Canonical SMILES [H]NCC(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@]([C@@H](C)O)([H])C4=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)CSSC[C@H](N6)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N7CCC[C@H]7C(O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)CC9=CN=CN9)=O)CSSC[C@H](N4)C(NCC(N[C@@H](CC(C)C)C(N%10CCC[C@H]%10C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C%11=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)CSSC[C@H](N%11)C6=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
Formula C188H305N55O50S6• XCF3COOH M.Wt 0
Löslichkeit Water: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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