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3-keto Fusidic Acid (Synonyms: 3-keto FA, 3-Oxofusidic Acid)

Katalog-Nr.GC48457

An active metabolite of fusidic acid

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3-keto Fusidic Acid Chemische Struktur

Cas No.: 4680-37-9

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1mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

3-keto Fusidic acid (3-keto FA) is an active metabolite of the antibiotic fusidic acid .1 3-keto FA is active against M. tuberculosis (MIC99 = 1.25 µM).

1.Strydom, N., Kaur, G., Dziwornu, G.A., et al.Pharmacokinetics and organ distribution of C?3 alkyl esters as potential antimycobacterial prodrugs of fusidic acidACS Infect. Dis.6(3)459-466(2020)

Chemical Properties

Cas No. 4680-37-9 SDF
Überlieferungen 3-keto FA, 3-Oxofusidic Acid
Canonical SMILES C[C@@]12[C@@]3([C@](C[C@H]([C@@]1([H])[C@@]4([C@@]([C@@H](C(CC4)=O)C)([H])CC2)C)O)([H])/C([C@H](C3)OC(C)=O)=C(C(O)=O)\CC/C=C(C)\C)C
Formula C31H46O6 M.Wt 514.7
Löslichkeit Chloroform: slightly soluble,Methanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.9429 mL 9.7144 mL 19.4288 mL
5 mM 0.3886 mL 1.9429 mL 3.8858 mL
10 mM 0.1943 mL 0.9714 mL 1.9429 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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