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α-Conotoxin AuIB (trifluoroacetate salt) (Synonyms: GCCSYPPCFATNPDC)

Katalog-Nr.GC49097

A conotoxin and an antagonist of α3β4 subunit-containing nAChRs

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α-Conotoxin AuIB (trifluoroacetate salt) Chemische Struktur

Cas No.: N/A

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500 µg
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1 mg
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5 mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Conotoxin AuIB is a conotoxin that has been found in C. aulicus and has receptor antagonist and analgesic activity.1 It is a peptide antagonist of α3β4 subunit-containing nicotinic acetylcholine receptors (nAChRs; IC50 = 0.75 µM). It is greater than 100-fold selective for α3β4 subunit-containing nAChRs over those containing α2β2, α2β4, α3β2, α4β2, α4β4, or α1β1γδ subunits but does inhibit homomeric α7 nAChRs by 34% at 3 µM. Intrathecal administration of α-conotoxin AuIB (0.2 and 2 nmol/animal) reduces mechanical allodynia in a rat model of neuropathic pain induced by partial sciatic nerve ligation.2 It also reverses somatic signs of withdrawal in a mouse model of morphine withdrawal when administered intracerebroventricularly at doses of 1.75 and 3.5 pmol/animal.3

1.Luo, S., Kulak, J.M., Cartier, G.E., et al.α-Conotoxin AuIB selectively blocks α3 β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine releaseJ. Neurosci.18(21)8571-8579(1998) 2.Napier, I.A., Klimis, H., Rycroft, B.K., et al.Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic painNeuropharmacology62(7)2202-2207(2012) 3.Muldoon, P.P., Jackson, K.J., Perez, E., et al.The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studiesBr. J. Pharmacol.171(16)3845-3857(2014)

Chemical Properties

Cas No. N/A SDF
Überlieferungen GCCSYPPCFATNPDC
Canonical SMILES O=C1[C@@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@@H](CSSC3)C(N)=O)=O)CC(O)=O)=O)=O)CC(N)=O)=O)([H])[C@H](O)C)=O)C)=O)CC5=CC=CC=C5)=O)NC([C@@]6([H])N1CCC6)=O)NC(CN)=O)=O)=O)CO)=O)CC7=CC=C(C=C7)O)=O.OC(C(F)(F)F)=O
Formula C65H89N17O21S4·XCF3COOH M.Wt 1572.8
Löslichkeit Water: 5 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.6358 mL 3.179 mL 6.3581 mL
5 mM 0.1272 mL 0.6358 mL 1.2716 mL
10 mM 0.0636 mL 0.3179 mL 0.6358 mL
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