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(+)-δ-Cadinene

Katalog-Nr.GC49268

A sesquiterpene with antimicrobial and anticancer activities

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(+)-δ-Cadinene Chemische Struktur

Cas No.: 483-76-1

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50 mg
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100 mg
114,00 $
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-δ-Cadinene is a sesquiterpene that has been found in upland cotton (G. hirsutum) and has antibacterial, insecticidal, and anticancer activities.1,2,3,4 It is active against S. pneumoniae (MIC = 31.25 µg/ml) and induces mortality in A. stephensi, A. aegypti, and C. quinquefasciatus third instar larvae (LC50s = 8.23, 9.03, and 9.86 µg/ml, respectively).2,3 (+)-δ-Cadinene (10, 50, and 100 µM) induces apoptosis in and inhibits proliferation of OVCAR-3 human ovarian cancer cells.4

1.Davis, G.D., and Essenberg, M.(+)-δ-Cadinene is a product of sesquiterpene cyclase activity in cottonPhytochemistry39(3)553-567(1995) 2.PÉrez-LÓpez, A., Cirio, A.T., Rivas-Galindo, V.M., et al.Activity against Streptococcus pneumoniae of the essential oil and δ-cadinene isolated from Schinus molle fruitJ. Essent. Oil Res.23(5)25-28(2011) 3.Govindarajan, M., Rajeswary, M., and Benelli, G.δ-Cadinene, calarene and δ-4-carene from Kadsura heteroclita essential oil as novel larvicides against malaria, dengue and filariasis mosquitoesComb. Chem. High Throughput Screen.19(7)565-571(2016) 4.Hui, L.-M., Zhao, G.-D., and Zhao, J.-J.δ-Cadinene inhibits the growth of ovarian cancer cells via caspase-dependent apoptosis and cell cycle arrestInt. J. Clin. Exp. Pathol.8(6)6046-6056(2015)

Chemical Properties

Cas No. 483-76-1 SDF
Canonical SMILES CC([C@H]1[C@@]2([H])C(CCC(C)=C2)=C(CC1)C)C
Formula C15H24 M.Wt 204.4
Löslichkeit DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.8924 mL 24.4618 mL 48.9237 mL
5 mM 0.9785 mL 4.8924 mL 9.7847 mL
10 mM 0.4892 mL 2.4462 mL 4.8924 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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