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8Br-HA

Katalog-Nr.GC49347

An FHIT inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

8Br-HA Chemische Struktur

Cas No.: N/A

Größe Preis Lagerbestand Menge
5 mg
111,00 $
Auf Lager
10 mg
213,00 $
Auf Lager
25 mg
502,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50 = 0.12 µM).1 It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 µM, respectively).

1.Kawaguchi, M., Sekimoto, E., Ohta, Y., et al.Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitorsJ. Med. Chem.64(13)9567-9576(2021)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES O=C(OC1=C2C=CC(OCC(NO)=O)=C1Br)C3=C2CCCC3
Formula C15H14BrNO5 M.Wt 368.2
Löslichkeit DMF: 10 mg/ml,DMSO: 10 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7159 mL 13.5796 mL 27.1592 mL
5 mM 0.5432 mL 2.7159 mL 5.4318 mL
10 mM 0.2716 mL 1.358 mL 2.7159 mL
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Gewicht
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Konzentration
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Inhalt
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Berechnen

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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