CAY10561 (Synonyms: Pyrazolylpyrrole ERK Inhibitor) |
| Katalog-Nr.GC43167 |
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.
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Cas No.: 933786-58-4
Sample solution is provided at 25 µL, 10mM.
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The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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