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(+)-Cloprostenol (D-Cloprostenol) (Synonyms: DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α)

Katalog-Nr.GC30743

(+)-Cloprostenol (D-Cloprostenol) ist ein Prostaglandin F2α (PGF2α)-Analogon und zeigt eine selektive agonistische AktivitÄt am Prostaglandinrezeptor.

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(+)-Cloprostenol (D-Cloprostenol) Chemische Struktur

Cas No.: 54276-21-0

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10mM (in 1mL DMSO)
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1mg
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5mg
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10mg
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25mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [3H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes[2].

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch[1].

[1]. Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21. [2]. Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8.

Chemical Properties

Cas No. 54276-21-0 SDF
Überlieferungen DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α
Canonical SMILES OC(CCC/C=C\C[C@@H]1[C@H]([C@H](O)C[C@@H]1O)/C=C/[C@@H](O)COC2=CC(Cl)=CC=C2)=O
Formula C22H29ClO6 M.Wt 424.92
Löslichkeit DMSO: 100 mg/mL (235.34 mM); Ethanol: 50 mg/mL (117.67 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.3534 mL 11.7669 mL 23.5338 mL
5 mM 0.4707 mL 2.3534 mL 4.7068 mL
10 mM 0.2353 mL 1.1767 mL 2.3534 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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