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Cyclo(RGDyK) (trifluoroacetate salt) (Synonyms: c(RGDyK), cyclic-L-Arg-L-Gly-L-Asp-D-Tyr-L-Lys)

Katalog-Nr.GC49716

A cyclic peptide ligand of αVβ3 integrin

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Cyclo(RGDyK) (trifluoroacetate salt) Chemische Struktur

Cas No.: N/A

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1 mg
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5 mg
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10 mg
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25 mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Cyclo(RGDyK) is a cyclic peptide ligand of αVβ3 integrin (IC50 = 37.5 nM) that contains the αVβ3 integrin-binding sequence arginine-glycine-aspartate (RGD).1 It has been conjugated to radiolabels or fluorescent probes for the visualization of αVβ3-mediated neoangiogenesis or optical imaging of αVβ3-expressing tumors in live mice.2,1 Cyclo(RGDyK) has also been conjugated to the DNA topoisomerase I inhibitor SN38 and an SN38-releasing trigger moiety to form a prodrug that targets cells overexpressing αVβ3 integrin and induces cytotoxicity in KB human cervical carcinoma cells.3

1.Chen, X., Conti, P.S., and Moats, R.A.In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenograftsCancer Res.64(21)8009-8014(2004) 2.van Hagen, P.M., Breeman, W.A., Bernard, H.F., et al.Evaluation of a radiolabelled cyclic DTPA-RGD analogue for tumour imaging and radionuclide therapyInt. J. Cancer90(4)186-198(2000) 3.Huang, B., Desai, A., Tang, S., et al.The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug releaseOrg. Lett.12(7)1384-1387(2010)

Chemical Properties

Cas No. N/A SDF Download SDF
Überlieferungen c(RGDyK), cyclic-L-Arg-L-Gly-L-Asp-D-Tyr-L-Lys
Canonical SMILES O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)[C@H]1CC2=CC=C(C=C2)O.OC(C(F)(F)F)=O
Formula C27H41N9O8 • XCF3COOH M.Wt 619.7
Löslichkeit Ethanol: soluble,Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.6137 mL 8.0684 mL 16.1368 mL
5 mM 0.3227 mL 1.6137 mL 3.2274 mL
10 mM 0.1614 mL 0.8068 mL 1.6137 mL
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