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Emavusertib (Synonyms: CA-4948)

Katalog-Nr.GC52002

Emavusertib (CA-4948) ist ein potenter IRAK4/FLT3-Inhibitor mit Anti-Tumor-AktivitÄt.

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Emavusertib Chemische Struktur

Cas No.: 1801344-14-8

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1 mg
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5 mg
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10 mg
100,00 $
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Emavusertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4; IC50 = 31.7 nM).1 It is selective for IRAK4 over FMS-related tyrosine kinase 3 (FLT3), cyclin-dependent kinase 2 (Cdk2), Aurora A kinase, glycogen synthase kinase 3β (GSK3β), and muscle-associated receptor tyrosine kinase (MUSK) at 1 µM. Emavusertib inhibits IL-6 release mediated by toll-like receptor 2 (TLR2), TLR5, or IL-1 receptor (IL-1R) in isolated human whole blood (IC50s = 989, 696, and 1,375 nM, respectively). In vivo, emavusertib (25-200 mg/kg) reduces tumor volume in an OCI-Ly3 diffuse large B cell lymphoma (DLBCL) mouse xenograft model.

1.Gummadi, V.R., Boruah, A., Ainan, B.R., et al.Discovery of CA-4948, an orally bioavailable IRAK4 inhibitor for treatment of hematologic malignanciesACS Med. Chem. Lett.11(12)2374-2381(2020)

Chemical Properties

Cas No. 1801344-14-8 SDF Download SDF
Überlieferungen CA-4948
Canonical SMILES O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@@H](O)C4)N=C5C(OC(N6CCOCC6)=N5)=C3
Formula C24H25N7O5 M.Wt 491.5
Löslichkeit DMSO: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0346 mL 10.1729 mL 20.3459 mL
5 mM 0.4069 mL 2.0346 mL 4.0692 mL
10 mM 0.2035 mL 1.0173 mL 2.0346 mL
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