EMT inhibitor-1 |
| Katalog-Nr.GC32914 |
EMT-Inhibitor-1 ist ein Inhibitor von Hippo-, TGF-β- und Wnt-Signalwegen mit AntitumoraktivitÄten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638526-21-2
Sample solution is provided at 25 µL, 10mM.
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EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].
EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β-mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].
[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.
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